The Advanced Setups allow player to further dictate the level of difficulty they wish to play, and to aim for higher scores.
First, deal each player 2 Bomb Cards (4 in a solitaire game) following the same rules as the standard game. Next, separate the Bomb Cards by their point value (number in upper right).
Shuffle each of these piles separately. As in the basic setup, decide which difficulty level you wish to play to determine how many Bomb Cards you will be using. Next, decide how many of each level card you want to use. For more difficult games, use more 3s and 4s. For easier games, use more 1s and 2s.
Example: You are playing a 3 player game on the Standard Difficulty, which calls for 21 Bomb Cards. You want to try to score a lot of points, so you decide to use seven level 4, seven level 3, four level 2, and 3 level 1 Bomb Cards.
Once you have your card levels chosen, you can set up in one of two ways:
Single Deck
Shuffle your chosen cards together along with the appropriate number of Fuse Cards (as described in the basic Setup), and display the cards in the same way as the basic setup (a draw deck with 5 face-up cards).
Stacks
Shuffle each level of Bomb Card separately and place the stacks face-up in the middle of the table. Next, shuffle the Fuse Cards and place them as a face-down stack near the face-up stacks of Bomb Cards.
When a player defuses a Bomb Card he:
- MAY CHOOSE to reveal and activate a Fuse Card
- Chooses which Bomb Card to take from the face-up stacks
All other rules and scoring remain the same as in the Standard Game.
Icons
A # symbol means that the number on the die matters, but the number can be chosen by the player.
Example:
For this card, the player can choose which number to place, but all 3 dice must have the same number. And on the last spot, only a blue die is acceptable.
The 
means that the color on the die matters, but the color can be chosen by the player.
Example:
For this card, the player can choose which colors to place, but each die must be a different color than the one(s) it is adjacent to.
A white background on a die means that any color die can be used. (there are no white dice)
Example:
This stack must be started with a 3, but any color 3 will work.
A split on a die means that either type of die will work. For example, in the previous card, the top of the stack could be any Yellow die, or any color 1.
A > or < means that the adjacent dice must be greater than or less than in value. The die symbols are bigger and smaller to make it easy to recognize which need to be higher numbers and which need to be lower.
Example:
This stack requires that the dice have higher numbers toward the top of the stack.
For example: 2 < 4 < 5 < 6.
A ? means that any die can be placed in this space.
Example:
This stack of 5 dice can have any die in 4 of the spaces, but the third die must be a Yellow 1.
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